Putative Tumor-Suppressive Function of Krüppel-Like Factor 4 in Primary Lung Carcinoma
نویسندگان
چکیده
منابع مشابه
Putative tumor-suppressive function of Kruppel-like factor 4 in primary lung carcinoma.
PURPOSE Krüppel-like factor 4 (KLF4) is a zinc-finger protein that plays important roles in stem cells and the development of gastric cancers. However, the role of KLF4 in primary lung cancer is unknown. The purpose of this study is to determine possible roles of KLF4 in lung cancer. EXPERIMENTAL DESIGN The KLF4 expression in primary lung cancer tissues and case-matched normal lung tissues we...
متن کاملHuman Cancer Biology Putative Tumor-Suppressive Function of Krüppel-Like Factor 4 in Primary Lung Carcinoma
Purpose:Krüppel-like factor 4 (KLF4) is a zinc-fingerprotein that plays important roles in stem cellsandthedevelopmentofgastriccancers.However, theroleofKLF4 inprimary lungcancer is unknown. The purpose of this study is to determine possible roles of KLF4 in lung cancer. Experimental Design: The KLF4 expression in primary lung cancer tissues and casematched normal lung tissueswere determinedbyp...
متن کاملEpigenetic alterations of Krüppel-like factor 4 and its tumor suppressor function in renal cell carcinoma.
Krüppel-like factor 4 (KLF4) is a transcription factor that can have divergent functions in different malignancies. The expression and role of KLF4 in renal cell cancer remain unclear. The purpose of this study is to determine epigenetic alterations and possible roles of KLF4 in renal cell carcinoma. The KLF4 expression in primary renal cell cancer tissues and case-matched normal renal tissues ...
متن کاملOpposing effects of Krüppel-like factor 4 (gut-enriched Krüppel-like factor) and Krüppel-like factor 5 (intestinal-enriched Krüppel-like factor) on the promoter of the Krüppel-like factor 4 gene
KLF4 (Krüppel-like factor 4 or gut-enriched Krüppel-like factor, GKLF) and KLF5 (Krüppel-like factor 5 or intestinal-enriched Krüppel-like factor, IKLF) are two closely related members of the zinc finger-containing Krüppel-like factor family of transcription factors. Although both genes are expressed in the intestinal epithelium, their distributions are different: Klf4 is primarily expressed in...
متن کاملKrüppel-like factor 4 regulates macrophage polarization.
Current paradigms suggest that two macrophage subsets, termed M1 and M2, are involved in inflammation and host defense. While the distinct functions of M1 and M2 macrophages have been intensively studied - the former are considered proinflammatory and the latter antiinflammatory - the determinants of their speciation are incompletely understood. Here we report our studies that identify Krüppel-...
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2009
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-09-0310